The Giant Mole (Talpidae wysoniam) is a boss found in the Mole Hole, just under Falador Park, alongside some baby moles. The Giant Mole's origin and creation are described as "a slight accident involving a bottle of Malignius-Mortifer's-Super-Ultra-Flora-Growth-Potion" when Wyson the gardener poured it on his plants.

The Giant Mole is accessed by digging with a spade on top of the park's mole hills. The tunnels are dark and the player will receive damage without a light source. An inextinguishable light source is recommended, such as a bullseye lantern, abyssal lantern, mining helmet, bruma torch, Kandarin headgear, or Firemaking cape. Any candles, torches, or oil lamps will be extinguished if she retreats within melee range. A tinderbox is needed to relight extinguished light sources. Furthermore, if a player has completed the quest Making Friends With My Arm and has lit the Fire of Eternal Light within the lair, they will no longer need to carry a light source in their inventory.

Players can also fight the Giant Mole in a group or by themselves via a private instance by the spade at the north-western entrance for a fee of 25,000 coins (12,500 with completion of the hard combat achievements). This cost is halved if the player is an ironman.

The Giant Mole is popular for its mole skin and mole claw drops, which can be traded to Wyson for unique bird nests, and it is one of the only sources of consistent bird nests. Bird nests can be crushed, which is an ingredient for making Saradomin brews. It is also killed for its immaculate mole skin drop, used in creating the gem sack or traded to Wyson for five unique bird nests.